Donghoon’s research has primarily focused on cancer genomics. He works on developing computational methods that integrate genomic, transcriptomic, and epigenomic signals from various next-generation functional sequencing assays. Using a comprehensive set of functional elements and an accurate regulatory network, he works on interpreting non-coding mutations and gene regulation. In particular, he is interested in studying the roles of epigenetics and chromatin structure on transcriptional and splicing regulation in cancer. Using integrative approach, he plans to decipher the hidden messages buried within the epigenetic landscape.